Paul A. Friedman, M.D.
President and Chief Executive Officer

David C. Hastings
Executive Vice President, Chief Financial Officer

John A. Keller, Ph.D.
Executive Vice President and Chief Business Officer

Brian W. Metcalf, Ph.D.
Executive Vice President and Chief Drug Discovery Scientist

Patricia A. Schreck
Executive Vice President, General Counsel

Paula J. Swain
Executive Vice President, Human Resources

Paul A. Friedman, M.D.

President and Chief Executive Officer

Paul A. Friedman joined Incyte in 2001 as chief executive officer and a director.

From 1994 to 1998 Dr. Friedman served as president of R & D for the DuPontMerck Pharmaceutical Company and from 1998 to 2001 as the president of DuPont Pharmaceuticals Research Laboratories, a wholly-owned subsidiary of the DuPont Company. From 1991 to 1994, he served as senior vice president at Merck Research Laboratories. Prior to his work at Merck and DuPont, Dr. Friedman was an associate professor of medicine and pharmacology at Harvard Medical School.

Dr. Friedman is a diplomate of the American Board of Internal Medicine, member of the American Society of Pharmacology and Experimental Therapeutics, member of the American Society of Clinical Investigation and member of the American Society of Biological Chemistry. He received his A.B. in biology from Princeton University and his M.D. from Harvard Medical School.

David C. Hastings

Executive Vice President, Chief Financial Officer

David C. Hastings joined Incyte as executive vice president and chief financial officer in October 2003.

Before joining Incyte, Mr. Hastings was chief financial officer and treasurer at ArQule, Inc. Prior to joining ArQule, he was with Genzyme, as vice president, corporate controller, and prior to Genzyme he spent three years as director of finance at Sepracor, Inc. From 1985 to 1994, Mr. Hastings was with PriceWaterhouseCoopers.

Mr. Hastings is a Certified Public Accountant and received his B.A. in economics from the University of Vermont.

John A. Keller, Ph.D.

Executive Vice President and Chief Business Officer

John A. Keller joined Incyte as executive vice president and chief business officer in September 2003.

Prior to joining Incyte, Dr. Keller was vice president, business development in GlaxoSmithKline's Worldwide Business Development group. Previously, he was vice president and director in the Alliance and Technology group for SmithKline Beecham Research and Development.

Dr. Keller received his B.A. in biology from Johns Hopkins University, and his Ph.D. in microbiology from Rutgers University.

Brian W. Metcalf, Ph.D.

Executive Vice President and Chief Drug Discovery Scientist

Brian W. Metcalf joined Incyte in February 2002 as executive vice president and chief drug discovery scientist.

From March 2000 to February 2002, Dr. Metcalf served as senior vice president and chief scientific officer of Kosan Biosciences, Incorporated. From December 1983 to March 2000, Dr. Metcalf held a number of executive management positions with SmithKline Beecham, including senior vice president, discovery chemistry and platform technologies. Prior to joining SmithKline Beecham, Dr. Metcalf held positions with Merrell Research Center from 1973 to 1983.

Dr. Metcalf received his B.S. and Ph.D. in organic chemistry from the University of Western Australia.

Patricia A. Schreck

Executive Vice President, General Counsel

Patricia A. Schreck joined Incyte as our executive vice president and general counsel in December 2003.

Prior to joining Incyte, Ms. Schreck was chief patent counsel at Elan Drug Delivery, Inc. Previously, she served as general counsel for Genomics Collaborative, Inc. and diaDexus, Inc. (a SmithKline Beecham & Incyte joint venture). From 1992 through 1998, Ms. Schreck held a variety of senior patent and corporate legal positions at SmithKline Beecham. Ms. Schreck holds a B.A. in Chemistry and Biology from University of Colorado and a J.D. from Villanova University School of Law. Ms. Schreck is admitted to practice before the United States Patent Bar.

Paula J. Swain

Executive Vice President, Human Resources

Paula J. Swain joined Incyte in January 2002 and serves as executive vice president of human resources.

Prior to joining the company, Ms. Swain spent nearly ten years with DuPont Pharmaceuticals Company (acquired by Bristol-Myers Squibb Company in 2001) where she served as vice president and senior vice president of human resources. She has also held human resource planning and employee relations positions with Chase Manhattan Bank, Marine Midland Bank and Delaware Trust Company.

Ms. Swain received her B.A. in psychology from Rockhurst College and graduated from the strategic human resources planning program at Harvard Business School.