Dermatology 

Over the last 18+ years, our science-first approach and heritage in immunology has formed the foundation of our company. We are committed to discovering and developing best-in-class medicines to bring innovative solutions to patients in need, including those with dermatologic conditions.

Our research and development efforts in Dermatology are initially focused on leveraging our cross-program knowledge of the JAK-STAT pathway and exploring the potential of JAK inhibition for a number of immune-mediated dermatologic conditions with a high unmet medical need, including atopic dermatitis, vitiligo, and hidradenitis suppurativa.

Research has shown that over-activation of the JAK-STAT pathway is critical to the pathogenesis of many immune-mediated dermatologic conditions. We strive to identify and develop therapies to modulate immune pathways driving uncontrolled inflammation to help restore normal immune function and bring the body closer to homeostasis.

Disease Areas of Interest

  • Atopic dermatitis (AD) is a common chronic disease characterized by inflammation of the skin. Signs and symptoms of AD include irritated and itchy skin that can cause red lesions that may ooze and crust.1 Patients with AD are also more susceptible to bacterial, viral and fungal infections.2 Clinical characteristics of the disease can lead to significant morbidity, including sleep disturbances and high quality of life burden to patients and families.3-8
  • Vitiligo is a chronic autoimmune disease characterized by depigmentation of skin that results from the loss of pigment-producing cells known as melanocytes. It affects approximately 0.5 percent to 2.0 percent of the population globally9 and there are no U.S. Food and Drug Administration (FDA) or European Medicines Agency (EMA)-approved drug therapies for the treatment of vitiligo. It can occur at any age, although many patients with vitiligo will experience initial symptoms before the age of 20.10 Vitiligo is associated with quality-of-life impairments11,12 and patients are at an increased risk for comorbidities and mental health disorders, including depression.12,13
  • Hidradenitis suppurativa also known as acne inversa, is an inflammatory skin condition characterized by painful bumps and recurrent lesions under the skin which occur in the armpit, groin, breast and anal regions of the body.14 The condition typically begins during puberty and is often most active between the ages of 20 and 40 years. It has a significant impact on quality of life and can be debilitating for some patients.14
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