Dermatology Research: Immune-Mediated Dermatologic Conditions

Our research and development efforts in dermatology are initially focused on leveraging our knowledge of the JAK-STAT pathway. We are exploring the potential of JAK inhibition for a number of immune-mediated dermatologic conditions with a high unmet medical need, including atopic dermatitis, vitiligo and hidradenitis suppurativa.

Research has shown that the JAK-STAT pathway mediates the cellular effects of cytokines involved in the pathogenesis of many immune-mediated dermatologic conditions. We strive to identify and develop therapies to modulate immune pathways driving uncontrolled inflammation to help restore normal immune function and bring the body closer to homeostasis.

Disease Areas of Interest

Atopic dermatitis

Atopic dermatitis (AD)—the most common type of eczema—is an immune-mediated skin condition that causes irritation and itch.

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Atopic dermatitis (AD) is a common chronic disease characterized by inflammation of the skin. Signs and symptoms of AD include irritated and itchy skin that can cause red lesions that may ooze and crust¹. Patients with AD are also more susceptible to bacterial, viral and fungal infections². The clinical signs and symptoms of the disease can have a profound impact on a patient’s quality of life^3-8.

Vitiligo

Vitiligo is a condition that causes the skin to lose its pigment cells (melanocytes), often resulting in discolored patches of the skin.

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Vitiligo is a chronic autoimmune disease characterized by depigmentation of skin that results from the loss of pigment-producing cells known as melanocytes. Overactivity of the JAK signaling pathway is believed to drive inflammation involved in the pathogenesis and progression of vitiligo. It affects approximately 0.5% to 2.0% of the population globally⁹. In the United States, more than 1.5 million people are diagnosed with vitiligo¹⁰. The overall prevalence of the condition is estimated to be approximately 2–3 million¹¹, with the majority of patients (approximately 85%) suffering from nonsegmental vitiligo¹². Vitiligo can occur at any age, although many patients with vitiligo will experience initial onset before the age of 30¹³. Vitiligo is associated with quality-of-life impairments^14,15and patients are at an increased risk for comorbidities and mental health disorders, including depression¹⁶.

Hidradenitis suppurativa

Red, painful lumps can develop under the skin for many reasons—including a condition called hidradenitis suppurativa.

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Hidradenitis suppurativa, also known as acne inversa, is an inflammatory skin condition that causes painful bumps to form in the armpit, groin, breast and anal regions of the body¹⁷. The condition typically begins during puberty and is often most active between the ages of 20 and 40 years. Some of the bumps can eventually lead to disfiguring scars. It has a significant impact on daily life and can be debilitating for some patients¹⁷.

PRURIGO NODULARIS

Prurigo nodularis is a condition that causes itchy bumps on the skin called “nodules” that appear after excessive scratching.

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Prurigo nodularis is a chronic inflammatory skin disease characterized by intense itch and thickened red bumps, typically on the arms, legs and trunk¹⁸. Sometimes the bumps may be painful and the constant itch can affect sleep quality¹⁸. Prurigo nodularis appears to be more common in older individuals and can have a substantial impact on a patient’s quality of life¹⁸.

LICHEN SCLEROSUS

Lichen sclerosus is a chronic relapsing inflammatory skin condition that causes white scaly plaques that usually form in the anogenital area of the body.

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Lichen sclerosus affects women more often than men and is associated with intolerable itch, which can lead to bleeding and scarring, and ultimately, drastic changes to genital anatomy¹⁹. There is an increased risk of squamous cell carcinoma if left untreated^20,21.

LICHEN PLANUS

Lichen planus is a chronic inflammatory disorder of the skin that may also present on the nails and in the mouth.

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Lichen planus can cause lesions, bumps or plaques on the skin that are itchy and purple. Onset of the condition usually affects the wrists, forearms and legs. Lichen planus occurs equally in males and females and tends to appear between 50 to 70 years of age^22,23. While itch is considered the most bothersome symptom²⁴, the condition is associated with relatively high rates of depression and anxiety²⁵.

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Medical Information

Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you are seeking medical information on our products, or wish to meet with a Medical Science Liaison, please visit IncyteMI.com.

To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Medical Information by calling 1-855-4-MEDINFO (1-855-463-3463).

Learn more about Opzelura^®
(ruxolitinib) cream

For HCPs

Global Medical Information

Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you need medical information or have a medical question, please visit incyteglobalmedicalinformation.com.

To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Global Medical Information.

Resources

United States

FOR PATIENTS

Start from Scratch

This site is a resource for those living with atopic dermatitis (AD). It was informed by people with AD, as well as advocates, and aims to provide information about the science behind AD and help empower patients to have more productive conversations with their dermatologists.

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IncyteCARES

Through IncyteCARES—a patient support and assistance program for eligible patients prescribed Jakafi, Pemazyre, or Opzelura—we strive to implement initiatives that support patients and remove barriers to accessing these medicines in the U.S. Our team can help patients with understanding their insurance coverage, exploring financial assistance options and providing as-needed support.

Learn About IncyteCARES

FOR HEALTHCARE PROFESSIONALS

Medical Information

Incyte is committed to providing timely and accurate product information to healthcare professionals upon request. If you are seeking medical information on our products, or wish to meet with a Medical Science Liaison, please visit IncyteMI.com.

To report a possible Adverse Event or Product Complaint related to an Incyte product, contact Incyte Medical Information by calling 1-855-4-MEDINFO (1-855-463-3463).

References

Developing the Next Generation of Dermatology Treatments

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