At Incyte, our research is grounded in the relentless pursuit of scientific excellence and the conviction that the advancement of basic science can drive the discovery of innovative medicines for patients. Our world-class researchers are focused on transforming the treatment of cancer and inflammatory and autoimmune conditions, and are advancing a diversified portfolio of clinical candidates.


Molecular Targets

Clinical Candidates


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Updated as of November 6, 2020

1. Jakafi marketed by Incyte in the U.S.; ruxolitinib licensed to Novartis ex-U.S. 2. Adults with intermediate or high-risk myelofibrosis 3. Adults with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea 4. Adults and pediatric patients 12 years and older with steroid-refractory acute GVHD 5. Adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with a FGFR2 fusion or other rearrangement as detected by an FDA-approved test 6. Co-commercialization in the U.S. with MorphoSys 7. Development in collaboration with MorphoSys 8. In combination with lenalidomide in adults with relapsed or refractory DLBCL not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant 9. European rights to Iclusig licensed from ARIAD 10. Adults with chronic phase, accelerated phase, or blast phase CML who are resistant to dasatinib or nilotinib; who are intolerant to dasatinib or nilotinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation 11. Adults with Ph+ ALL who are resistant to dasatinib; who are intolerant to dasatinib and for whom subsequent treatment with imatinib is not clinically appropriate; or who have the T315I mutation 12. Certain development programs conducted in collaboration with Novartis 13. In collaboration with MacroGenics 14. In collaboration with Merus 15. Licensed from Calithera 16. Discovery collaboration with Agenus 17. Worldwide rights to baricitinib licensed to Lilly 18. Approved in multiple territories globally for certain patients with moderate to severe rheumatoid arthritis 19. Approved in Europe for adults with moderate to severe atopic dermatitis who are candidates for systemic therapy 20. Worldwide rights to capmatinib licensed to Novartis 21. Approved in the U.S. and Japan for certain patients with NSCLC with MET exon 14 skipping (METex14) mutation


The efficacy and safety of the investigational compounds discussed have not been established. There is no guarantee that these compounds will become commercially available for the use(s) under investigation.

Clinical Trials

We have numerous clinical trials underway across Oncology and Inflammation & Autoimmunity research areas. Incyte-sponsored studies can be found at

Incyte also supports significant independent research aimed at advancing the study of our products. A team of professionals scrutinizes all proposals submitted to Incyte for scientific merit and alignment with Incyte’s research goals. If you are interested in submitting a research proposal, please visit our online portal at

Learn more about our target molecules currently in clinical development

For questions concerning Investigator Initiated Research conducted outside of the US, please contact Incyte at

For questions concerning Investigator Initiated Research conducted in the US, please contact Incyte at